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Prognosis and assessment

Quail MA, Russell RK, Van Limbergen JE et al. Inflamm Bowel Dis 2009;15:756–9.

The utility of fecal calprotectin in the diagnostic work-up of children with IBD was evaluated in this study. Its role alongside standard blood tests used in IBD was also assessed. The investigators found that fecal calprotectin was significantly more likely to be raised than any of the commonly employed blood tests at IBD diagnosis. They conclude that fecal calprotectin measurement is a significant advance when used alongside routine blood tests in the diagnosis of pediatric IBD.

Fecal calprotectin is a neutrophil cytosolic protein with antimicrobial properties. It is present at an increased concentration in stool in those with gastrointestinal inflammation. The normal fecal calprotectin level in children aged 4–17 years is <50 µg/g, although neonatal levels are higher, at a median of 167 µg/g. The test for fecal calprotectin is simple and noninvasive, and is therefore of considerable value in the pediatric population in which the diagnosis of IBD may be difficult and a delay to diagnosis is common.

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February 08, 2012

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Produced and published by Remedica Medical Education and Publishing Limited.

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Inflammatory Bowel Disease Monitor

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Prognosis and assessment

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LATEST ARTICLES

Leading Articles

Mucosal Healing and Treatment Efficacy in IBD

Gert van Assche, MD, PhD, Séverine Vermeire, MD, PhD, and Paul Rutgeerts, MD

Management of Lack and Loss of Response to Anti-Tumor Necrosis Factor Therapy

Anne Christine W Vos, Herma H Fidder, MD, PhD, Gijs R van den Brink, MD, PhD, and Daniel W Hommes, MD, PhD

Management of Postoperative Crohn’s Disease

Joseph Rodemann, MD, and Miguel Regueiro, MD

Clinical Reviews

Clinical observations and research

Therapeutics research

Prognosis and assessment

Pathogenesis

Epidemiology

Meeting Reports

Digestive Disease Week 2009  (DDW 2009): Key Updates in  IBD Clinical Research

Uma Mahadevan, MD, and Fernando Velayos, MD, MPH

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February 08, 2012 CLOSE To subscribe to updates from this journal click Confirm. Updates will be displayed in your default RSS reader. Produced and published by Remedica Medical Education and Publishing Limited. » Contact us

Prognosis and assessment

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LATEST ARTICLES

Leading Articles

Gert van Assche, MD, PhD, Séverine Vermeire, MD, PhD, and Paul Rutgeerts, MD

Anne Christine W Vos, Herma H Fidder, MD, PhD, Gijs R van den Brink, MD, PhD, and Daniel W Hommes, MD, PhD

Joseph Rodemann, MD, and Miguel Regueiro, MD

Clinical Reviews

Meeting Reports

Uma Mahadevan, MD, and Fernando Velayos, MD, MPH

Our most popular articles

February 08, 2012

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