May 24, 2012

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100 Genes for IBD... Whatever Next!? 

James C Lee, MD^1,2, and Miles Parkes, MD²

The advent of genome-wide association scanning (GWAS) has revolutionized our understanding of complex disease genetics, with Crohn’s disease [1–3] and ulcerative colitis (UC) [4–7] being among the chief beneficiaries of this new technology. By genotyping single-nucleotide polymorphisms (SNPs) throughout the entire genome, GWAS interrogates over 70% of common variation genome-wide. The technique is hypothesis-free, with associated loci identified purely on the statistical grounds of allele frequency differing significantly between cases and controls. A consequent strength is that the results can drive completely new insights regarding causal mechanisms – such as the role of autophagy in Crohn’s disease, a cellular process that had never previously been considered as contributing to disease pathogenesis.

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LATEST ARTICLES

Leading Articles
- Lymphoma and IBD:  What is the Actual Risk? 
  
  Guillaume Pineton de Chambrun, MD¹, Laurent Peyrin-Biroulet, MD², Bénédicte De Vroey, MD¹, and Jean-Frédéric Colombel, MD¹
  
  ¹Clinique des Maladies de l’Appareil Digestif et de la Nutrition, Hôpital Claude Huriez, CHRU Lille, and²Service d’Hépato-Gastroentérologie, CHU de Nancy, Vandœuvre-lès-Nancy, France
  
  With the increased use of immunosuppressive and biological agents for the treatment of IBD, the risk of serious side effects, especially lymphoma, has become a major concern for clinicians managing patients with Crohn’s disease and ulcerative colitis.
- 100 Genes for IBD... Whatever Next!? 
  
  James C Lee, MD^1,2, and Miles Parkes, MD²
  
  ¹Cambridge Institute for Medical Research, University of Cambridge, and ²Department of Gastroenterology, Addenbrooke’s Hospital, Cambridge, UK
  
  The advent of genome-wide association scanning has revolutionized the search for genetic loci associated with IBD. Recent meta-analyses from the International IBD Genetics Consortium have increased the number of confirmed IBD susceptibility genes and loci to 100.
- Noninvasive Imaging in  Crohn’s Disease Assessment  
  
  Emma Calabrese, MD, PhD, and Francesco Pallone, MD
  
  Cattedra di Gastroenterologia, Dipartimento di Medicina, Università di Roma “Tor Vergata”, Rome, Italy
  
  Several radiological and endoscopic techniques are now available for the study of IBD; each technique is characterized by a distinct profile of advantages and disadvantages. In everyday practice, the choice of the technique to be used depends upon its availability and careful evaluation of its diagnostic accuracy, clinical usefulness, safety, and cost.
Clinical Reviews
Meeting Reports
- Report from United European Gastroenterology Week 2010 
  
  Anne Christine W Vos, MD, and Marjolijn Duijvestein, MD, PhD
  
  Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
  
  More than 14 000 participants attended the 18th United European Gastroenterology Week (UEGW) in sunny Barcelona, Spain, from October 23–27, 2010. The annual UEGW is a joint congress of four organizations: the United European Gastroenterology Federation, the World Gastroenterology Organization, the World Organization of Digestive Endoscopy (OMED), and the British Society of Gastroenterology.

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