February 23, 2012

CLOSE

To subscribe to updates from this journal click Confirm. Updates will be displayed in your default RSS reader.

Produced and published by Remedica Medical Education and Publishing Limited.

» Contact us

Inflammatory Bowel Disease Monitor

» Advanced search

Please note that only limited free access to this journal is available in your country or territory.

To access the full content of this article you must purchase it (US$9.49). After payment of this one-off fee, you will gain unrestricted online access to the article and a PDF version sent to your email.

As part of our special introductory offer, after purchasing this article you will have unrestricted access to all the articles in this issue for free!

Registered users can purchase/access the article by logging in below. To register for free click here

Registered users login here:

Email Address:
Password:

If you have forgotten your password click here


0 rating

Is Diet Involved in the Etiology of Ulcerative Colitis and Crohn’s Disease? A Review of the Experimental and Epidemiological Literature 

Punyanganie de Silva, MBBS, MRCP(UK)¹, Elizabeth K Lund, PhD²,  Simon Chan, MB BChir, MRCP, PhD^1,3, and Andrew R Hart, MD^1,3

The consequences of a diagnosis of Crohn’s disease or ulcerative colitis (UC) are well known. They include an impaired quality of life (QoL) and a requirement for regular medication and surgery, together with an increased risk of complications including colorectal cancer [1–3]. The etiology of the two illnesses is unknown, although recognized risk factors are genetics and a family history [4], smoking [5], and appendectomy [6]. Environmental factors are paramount as only changes in these can explain the large increases in incidence during the 20th century and the adoption of the incidence pattern in migrants who move from low to high risk areas [7,8]. One such environmental factor that may be important is diet. Experimental studies have provided key data on how nutrients may be involved, although confirmation of these data in epidemiological studies is required. Such investigations are difficult for several methodological reasons. This review will focus predominantly on diet in the etiology of IBD, but not provide detailed information on dietary manipulation in the clinical treatment of patients. We will describe laboratory-based investigations supporting a role for diet, outline the most robust epidemiological methods for studying diet, and finally review epidemiological etiological studies in IBD.

Please login or register to continue reading this article

Return to top

Post Page On

LATEST ARTICLES

Leading Articles
- Characterizing the Microbiota in IBD
  
  Richard Hansen, MB ChB^1,2, Emad El-Omar, MD¹, and Georgina L Hold, PhD¹
  
  ¹Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen; ²Child Health, University of Aberdeen, Royal Aberdeen Children’s Hospital, Foresterhill, Aberdeen, UK
  
  The genetic revolution in IBD has resulted in the detection of 99 susceptibility loci and moved the focus of research to the host–environment interface and the role of the innate immune system. The most important element of this interface is thought to be the microbial residents of the gastrointestinal (GI) tract, the so-called microbiota.
- Confocal Laser Endomicroscopy for IBD Assessment: An Update
  
  Helmut Neumann, MD, PhD¹, Raja Atreya, MD, PhD¹, Michael Vieth, MD, PhD²,  and Markus F Neurath, MD, PhD¹
  
  ¹Department of Medicine I, University of Erlangen–Nuremberg, Erlangen, and ²Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany
  
  Advanced endoscopic imaging with virtual histology has become clinical reality since the introduction of confocal laser endomicroscopy (CLE) in 2004. In the meantime, various studies have shown the explicit potential of CLE for the diagnosis and characterization of different disease entities, including IBD.
- Is Diet Involved in the Etiology of Ulcerative Colitis and Crohn’s Disease? A Review of the Experimental and Epidemiological Literature 
  
  Punyanganie de Silva, MBBS, MRCP(UK)¹, Elizabeth K Lund, PhD²,  Simon Chan, MB BChir, MRCP, PhD^1,3, and Andrew R Hart, MD^1,3
  
  ¹Norfolk & Norwich University Hospital NHS Trust, ²School of Biological Sciences, University of East Anglia, and³Norwich Medical School, University of East Anglia, Norwich, UK
  
  The increasing adoption of a “Western diet” and the differences in food intake between low- and high-risk areas for IBD suggest that diet may be an important etiological factor.
Clinical Reviews
Meeting Reports
- Digestive Disease Week 2011:  An Update on IBD Basic Science 
  
  Atsushi Sakuraba, MD
  
  Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Chicago, Chicago, IL, USA
  
  Digestive Disease Week (DDW) 2011 brought together both clinicians and basic scientists to present and discuss novel aspects of gastrointestinal and liver diseases. The current report summarizes the highlights of mostly unpublished basic research in the field of IBD presented at the meeting.
- Digestive Disease Week 2011:  An Update on IBD Clinical Research 
  
  Frank Hoentjen, MD, PhD
  
  Inflammatory Bowel Disease Center, University of Chicago, Chicago, IL, USA
  
  Digestive Disease Week (DDW) 2011 was held from May 7–10, 2011, in Chicago, IL, USA. IBD, in particular biological therapy in IBD, was a popular topic, and these sessions were well attended. This report will summarize the most important clinical findings in IBD research presented at this year’s meeting.

Our most popular articles

READ

Is Diet Involved in the Etiology of Ulcerative Colitis and Crohn’s Disease? A Review of the Experimental and Epidemiological Literature 
(Volume 12 Issue 1 / Leading Articles)
Adherent–Invasive Escherichia coli: Role in Crohn’s Disease Pathogenesis
(Volume 10 Issue 3 / Leading Articles)
Enteral Nutrition in IBD
(Volume 09 Issue 4 / Leading Articles)
Diagnosis and Management of Anemia in IBD
(Volume 11 Issue 4 / Leading Articles)
Genetic Regulation of Epithelial Barrier Function: Recent Insights into the Pathogenesis of Inflammatory Bowel Disease
(Volume 08 Issue 4 / Leading Articles)
Lymphoma and IBD:  What is the Actual Risk? 
(Volume 11 Issue 3 / Leading Articles)

British Society of Gastroenterology Annual Meeting 2011
(Volume 11 Issue 4 / Meeting Reports)
1st British Society of Gastroenterology Supraregional Meeting 
(Volume 12 Issue 2 / Meeting Reports)

© Remedica 2012. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise without the prior permission of the copyright owners. While every effort is made by the publishers and editorial board to see that no inaccurate or misleading data, opinions, or statements appear in this journal, they wish to make it clear that the material contained in the publication represents a summary of the independent evaluations and opinions of the authors and contributors. As a consequence, the board, publishers, and any supporting company accept no responsibility for the consequences of any such inaccurate or misleading data or statements. Neither do they endorse the content of the publication or the use of any drug or device in a way that lies outside its current licensed application in any territory. For detailed information on any drugs or devices discussed in this publication, readers are advised to consult the manufacturer’s prescribing information.

Produced and published by Remedica Medical Education and Publishing Limited.

February 23, 2012

CLOSE

To subscribe to updates from this journal click Confirm. Updates will be displayed in your default RSS reader.

Produced and published by Remedica Medical Education and Publishing Limited.

» Contact us