Bucci C, Zingone F, Russo I et al. Clin Gastroenterol Hepatol 2013;11:1294–9.e1.
In this article, the authors investigated the immunological responses in non-celiac gluten sensitivity patients after their exposure to gliadin (a protein present in wheat), examining isolated samples of duodenal mucosa and peripheral blood basophils from these patients.
Although symptoms of non-celiac gluten sensitivity (NCGS) are triggered by ingestion of the wheat protein gliadin and may resemble those of celiac disease, NCGS is distinct from celiac disease and also has symptoms associated with autoimmune diseases such as Crohn’s disease. Because of a lack of objective diagnostic tests, either serological or histological, NCGS often goes undiagnosed. Moreover, because a gluten-free diet is recommended only for those patients who are diagnosed with celiac disease, many NCGS patients (who are not on such a diet) suffer from serious symptoms that put them at risk of complications of autoimmune disorders that could otherwise be quickly resolved. For this reason, specific histological markers are urgently needed.