Paper of the Month - November, 2011

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Acquisition of the rheumatoid arthritis HLA shared epitope through microchimerism

Yan Z, Aydelotte T, Gadi VK et al.
Arthritis Rheum 2011;63:640–4.

This study reported that rheumatoid arthritis (RA) patients who were genotypically negative for the shared epitope (SE) could acquire the SE through microchimerism via fetal–maternal cell exchange, suggesting that SE-encoding microchimerism could contribute to the RA risk.


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