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PATHOGENESIS

Lefèvre S, Knedla A, Tennie C et al. Nat Med 2009;15:1414–20.

The inflamed synovial tissue in rheumatoid arthritis (RA) consists of synovial fibroblasts and many inflammatory immune cells. The synovial fibroblasts in RA drive the destruction of cartilage by producing matrix-degrading enzymes and also have the ability to invade cartilage in vitro. Lefèvre et al. demonstrated in this study that these cells can migrate into cartilage in vivo thereby allowing the spread RA from affected to unaffected joints.

 

Active rheumatoid arthritis (RA) originates in few joints but will later affect many joints. A possible driver of this progression of disease is the dissemination of joint cells that have altered behavior, for example RA synovial fibroblasts (RASFs).

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