Diekema DJ, Messer SA, Boyken LB et al.
J Clin Microbiol 2009;47:3170–7.
The present authors determined the in vitro activities of fluconazole, voriconazole, posaconazole, amphotericin B
(AmB), anidulafungin, caspofungin, and micafungin against the less commonly encountered Candida spp. A total of 658 patient isolates were tested. Over 95% of the isolates were susceptible to the azoles and echinocandins. In contrast, only approximately 88% of the isolates tested were susceptible to AmB. There was significant antifungal variability with respect to species susceptibility patterns.
Over 95% of Candida bloodstream infections are caused by one of five species: Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Candida krusei. Although the in vitro susceptibilities of these species have been widely studied, similar data are generally lacking for the less commonly encountered Candida spp.