Davis JA, Horn DL, Marr KA et al.
Transpl Infect Dis 2009;11:432–7.
The present study included patients with cryptococcosis who were enrolled in the PATH (Prospective Antifungal Therapy Alliance) registry. Patients with HIV infection were found to have a higher risk of central nervous system (CNS) involvement than solid-organ transplant recipients. In addition, the use of calcineurin inhibitors resulted in a lower risk of CNS involvement.
Cryptococcus neoformans is a pathogen that frequently affects immunocompromised patients, including solid-organ transplant (SOT) recipients and patients with HIV infection. The aim of the present study was to compare the manifestations of central nervous system (CNS) cryptococcosis in these two groups of patients with different underlying immune dysfunction.