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Genomic Profiling of Aspergillus Spp. Pathogenicity

Liliana Losada, PhD1, Natalie D Fedorova, PhD1, and William C Nierman, PhD1,2

Aspergillosis is an umbrella term given to a wide variety of diseases caused by pathogenic moulds of the Aspergillus genus, which encompasses >200 species [1]. A fumigatus and A flavus are the most common causative agents of invasive aspergillosis (IA), a mould infection associated with high mortality rates. IA affects mostly immunocompromised individuals, but A fumigatus and A flavus are pathogenic to all humans in concentrated quantities. They can also cause allergic bronchopulmonary aspergillosis (ABPA) and mycotic sinusitis in allergic individuals [2,3], although other members of the species can also cause these conditions [1]. Human exposure to asexual spores (or conidia) is unavoidable as members of these species are ubiquitous in vegetable-matter composts and in most human habitats [3–5]. A recent survey of the fungi in the oral cavity showed that Aspergillus spp. could be detected in approximately 35% of normal oral microbiomes, further demonstrating the ubiquity of the species [6].

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