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Invertebrate Animal Models as Tools to Study Fungal Pathogenesis and Treatment

Maged Muhammed, MD, Jeffrey J Coleman, PhD, Themistoklis K Kourkoumpetis, MD, and Eleftherios Mylonakis, MD, PhD

The use of heterologous hosts has allowed scientists to learn more about the mechanism of the infection process, the pathogenesis of infectious microbes, and the immune response of the host, as well as enabling the in vivo evaluation of large compound libraries for antimicrobial activity. Several invertebrate model hosts have served scientists investigating these issues. The popularity of invertebrate models in host–pathogen interaction research is in part due to their inexpensiveness, their ability to be used in high-throughput screening assays, and the fact that their use circumvents the ethical issues arising from the use of mammalian systems.

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