Amphotericin B Resistance: Epidemiology, Mechanisms, and Clinical Relevance

Stephanie A Knechtel and Michael E Klepser
Ferris State University College of Pharmacy, Kalamazoo, MI, USA

Amphotericin B, a polyene antifungal, was once considered the gold standard for the management of a number of fungal infections. Despite several decades of use, resistance to amphotericin B has been seemingly slow to develop. Although innate resistance has been described among some Candida species and various molds including several Aspergillus species, reports of secondary resistance emerging while on therapy appear to be relatively scarce.
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