February 06, 2012

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The Journal of Viral Entry

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Volume 3 Issue 3

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Volume 3 Issue 3

Leading ArticlesClick to expand
- CD4⁺ T Cell Decline and Chronic Immune Activation in HIV Disease
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Leading Articles)
  
  Scott F Sieg
  
  Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
  
  Chronic immune activation is recognized as a key component in HIV pathogenesis. The high levels of T cell activation in HIV disease are associated with high levels of T cell proliferation and death. Immune activation also underlies changes in the lymph node microenvironment, including increased production of inflammatory cytokines and increased fibrosis.
  » Read more
- An Enhanced-Sensitivity Trofile™ HIV Coreceptor Tropism Assay for Selecting Patients for Therapy with Entry Inhibitors Targeting CCR5: A Review of Analytical and Clinical Studies
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Leading Articles)
  
  Jacqueline D Reeves, Eoin Coakley, Christos J Petropoulos, and Jeannette M Whitcomb
  
  Monogram Biosciences, South San Francisco, CA, USA
  
  The Trofile™ HIV coreceptor tropism assay (Monogram Biosciences, South San Francisco, CA, USA) determines whether a patient’s viral population is CCR5-tropic (R5), CXCR4-tropic (X4), or dual (R5X4)/mixed-tropic (D/M), and is currently the only clinically validated assay available to identify patients suitable to receive treatment with CCR5 antagonists. The original Trofile assay was validated to detect X4 and R5 variants that comprised 10% of a viral envelope population with 100% sensitivity, or 5% of a population with 85% sensitivity.
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- HIV type 1 Entry Correlates with Plasma Membrane Microdomain Lateral Assemblies of Receptors: Implications in HIV/AIDS Treatment
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Leading Articles)
  
  Anu Puri and Robert Blumenthal
  
  Nanobiology Program, Center for Cancer Research, The National Cancer
  Institute at Frederick, National Institutes of Health, Frederick, MD, USA
  
  HIV type 1 (HIV-1) enters permissive cells via a series of interactions between the viral envelope glycoprotein gp120–gp41 and the cell surface receptors CD4 and CXCR4 or CCR5, followed by fusion of the virus and host cell membranes. Lipid rafts – sphingolipid- and cholesterol-rich microdomains in the plasma membrane – have been proposed as platforms for recruitment and assembly of receptor(s) and viral fusion proteins subsequent to their interactions that lead to the fusion event.
  » Read more
Clinical ReviewsClick to expand
- Effect of single doses of maraviroc on the QT/QTc interval in healthy subjects
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more
- Population pharmacokinetic/ pharmacodynamic analysis of CCR5 receptor occupancy by maraviroc in healthy subjects and HIV-positive patients
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more
- A population pharmacokinetic meta-analysis of maraviroc in healthy volunteers and asymptomatic HIV-infected subjects
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more
- [1] Assessment of the absorption, metabolism, and absolute bioavailability of maraviroc in healthy male subjects
  [2] Assessment of the pharmacokinetics, safety and tolerability of maraviroc, a novel CCR5 antagonist, in healthy volunteers
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more
- Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugs
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more
- Binding modes of CCR5-targetting HIV entry inhibitors: partial and full antagonists
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more
- Suppression of dualtropic human immunodeficiency virus type 1 by the CXCR4 antagonist AMD3100 is associated with efficiency of CXCR4 use and baseline virus composition
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more
- Major clinical outcomes in antiretroviral therapy (ART)-naïve participants and in those not receiving ART at baseline in the SMART study
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more
- Immunogenetic basis of HIV-1 infection, transmission and disease progression
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more
- HIV-1 envelope glycoprotein-mediated fusion and pathogenesis: implications for therapy and vaccine development
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more
- Identification of a critical motif for the human immunodeficiency virus type 1 (HIV-1) gp41 core structure: implications for designing novel anti-HIV fusion inhibitors
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more
- In vivo emergence of vircriviroc resistance in a human immunodefiency virus type 1 subtype C-infected subject
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more
- Specific enfuvirtide-associated mutational pathways in HIV-1 gp41 are significantly correlated with an increase in CD4⁺ cell count, despite virological failure
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more
- Characterisation of the early steps of infection in primary blood monocytes by human immunodeficiency virus type 1
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more
- Virological consequences of early events following cell–cell contact between human immunodeficiency virus type 1-infected and uninfected CD4⁺ cells
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more
- Chemokine (C–C motif) receptor 5-using envelopes predominate in dual/mixed-tropic HIV from the plasma of drug-naïve individuals
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more
- The impact of HIV tropism on decreases in CD4 cell count, clinical progression, and subsequent response to a first antiretroviral therapy regimen
  
  in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)
  
  » Read more

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© Remedica 2012. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise without the prior permission of the copyright owners. While every effort is made by the publishers and editorial board to see that no inaccurate or misleading data, opinions, or statements appear in this journal, they wish to make it clear that the material contained in the publication represents a summary of the independent evaluations and opinions of the authors and contributors. As a consequence, the board, publishers, and any supporting company accept no responsibility for the consequences of any such inaccurate or misleading data or statements. Neither do they endorse the content of the publication or the use of any drug or device in a way that lies outside its current licensed application in any territory. For detailed information on any drugs or devices discussed in this publication, readers are advised to consult the manufacturer’s prescribing information.

Produced and published by Remedica Medical Education and Publishing Limited.

February 06, 2012 CLOSE To subscribe to updates from this journal click Confirm. Updates will be displayed in your default RSS reader. Produced and published by Remedica Medical Education and Publishing Limited. » Contact us

Latest Issue

Volume 3 Issue 3

Leading Articles

Scott F Sieg

Jacqueline D Reeves, Eoin Coakley, Christos J Petropoulos, and Jeannette M Whitcomb

Anu Puri and Robert Blumenthal

Clinical Reviews

Volume 3 Issue 3

Leading ArticlesClick to expand

in The Journal of Viral Entry (Volume 3 Issue 3 / Leading Articles)

Scott F Sieg

in The Journal of Viral Entry (Volume 3 Issue 3 / Leading Articles)

Jacqueline D Reeves, Eoin Coakley, Christos J Petropoulos, and Jeannette M Whitcomb

in The Journal of Viral Entry (Volume 3 Issue 3 / Leading Articles)

Anu Puri and Robert Blumenthal

Clinical ReviewsClick to expand

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

in The Journal of Viral Entry (Volume 3 Issue 3 / Clinical Reviews)

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February 06, 2012

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Produced and published by Remedica Medical Education and Publishing Limited.

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