February 23, 2012

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The Journal of Viral Entry

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Latest Issue

Volume 4 Issue 1

Leading ArticlesClick to expand
- Nature and Function of CCR5 in Immune Activation, HIV-1 Entry,  and Targeted Therapeutics
  
  in The Journal of Viral Entry (Volume 4 Issue 1 / Leading Articles)
  
  Samantha J Westrop, BSc¹, Graeme J Moyle, MD², and Nesrina Imami, MD, PhD¹
  
  ¹Department of Immunology, Imperial College London, and ²Department of Genitourinary Medicine,  Chelsea and Westminster Hospital, London, UK
  
  Since its identification as a coreceptor for viral entry into CD4+ cells, CCR5 has represented a possible therapeutic target in the battle against HIV-1. In the current article, the physiological function of CCR5, its use by HIV-1 to enter target cells, and its role in immune activation and susceptibility to disease are summarized.
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- Genotype Testing to Determine HIV Coreceptor Tropism
  
  in The Journal of Viral Entry (Volume 4 Issue 1 / Leading Articles)
  
  Eva Poveda, PhD, Eduardo Seclén, PhD, and Vincent Soriano, PhD, MD
  
  Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
  
  The development and approval of the first CCR5 antagonist, maraviroc, which exclusively acts against CCR5-tropic variants of HIV, has necessitated the determination of HIV coreceptor usage in the clinical setting.
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Case StudyClick to expand
- Can Stem-Cell Transplantation  with CCR5-Deficient Cells be  used to Treat Patients with HIV
  
  in The Journal of Viral Entry (Volume 4 Issue 1 / Case Study)
  
  Jörg Hofmann, PhD¹, Detlev H Krüger, MD¹, and Gero Hütter, MD²
  
  ¹Institute of Medical Virology, Helmut-Ruska-Haus, Charité University Medicine Berlin, Berlin, and ²Institute of Transfusion Medicine and Immunology, Universitätsmedizin Mannheim, Mannheim, Germany
  
  Almost 25 years have passed since the discovery of HIV and AIDS, and >25 antiviral drugs from various therapeutic classes are available at present. Despite these developments and the numerous educational campaigns that have been initiated worldwide, the numbers of HIV-infected patients in developing and industrialized countries are still increasing.
  » Read more
Clinical ReviewsClick to expand
- CCR5 Antagonists
  
  in The Journal of Viral Entry (Volume 4 Issue 1 / Clinical Reviews)
  
  » Read more
- Mechanisms of Viral Entry
  
  in The Journal of Viral Entry (Volume 4 Issue 1 / Clinical Reviews)
  
  » Read more
- New Therapeutic Approaches
  
  in The Journal of Viral Entry (Volume 4 Issue 1 / Clinical Reviews)
  
  » Read more
- Epidemiology
  
  in The Journal of Viral Entry (Volume 4 Issue 1 / Clinical Reviews)
  
  » Read more
- Tropism
  
  in The Journal of Viral Entry (Volume 4 Issue 1 / Clinical Reviews)
  
  » Read more
- HIV Transmission
  
  in The Journal of Viral Entry (Volume 4 Issue 1 / Clinical Reviews)
  
  » Read more
- Antiretroviral Therapy
  
  in The Journal of Viral Entry (Volume 4 Issue 1 / Clinical Reviews)
  
  » Read more
Meeting ReportsClick to expand
- Highlights from the 12th European AIDS Conference/European AIDS Clinical Society (EACS)
  
  in The Journal of Viral Entry (Volume 4 Issue 1 / Meeting Reports)
  
  Vincent Soriano, MD, PhD
  
  Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
  Cologne, Germany, November 11–14, 2009
  
  The 12th European AIDS Conference/European AIDS Clinical Society (EACS) took place in Cologne, Germany. More than 3000 attendees were present at this meeting, which was mainly focused on the clinical and therapeutic aspects of HIV.
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© Remedica 2012. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise without the prior permission of the copyright owners. While every effort is made by the publishers and editorial board to see that no inaccurate or misleading data, opinions, or statements appear in this journal, they wish to make it clear that the material contained in the publication represents a summary of the independent evaluations and opinions of the authors and contributors. As a consequence, the board, publishers, and any supporting company accept no responsibility for the consequences of any such inaccurate or misleading data or statements. Neither do they endorse the content of the publication or the use of any drug or device in a way that lies outside its current licensed application in any territory. For detailed information on any drugs or devices discussed in this publication, readers are advised to consult the manufacturer’s prescribing information.

Produced and published by Remedica Medical Education and Publishing Limited.

February 23, 2012 CLOSE To subscribe to updates from this journal click Confirm. Updates will be displayed in your default RSS reader. Produced and published by Remedica Medical Education and Publishing Limited. » Contact us

Latest Issue

Volume 4 Issue 1

Leading Articles

Samantha J Westrop, BSc1, Graeme J Moyle, MD2, and Nesrina Imami, MD, PhD1

Eva Poveda, PhD, Eduardo Seclén, PhD, and Vincent Soriano, PhD, MD

Case Study

Jörg Hofmann, PhD1, Detlev H Krüger, MD1, and Gero Hütter, MD2

Clinical Reviews

Meeting Reports

Vincent Soriano, MD, PhD

Volume 4 Issue 1

Leading ArticlesClick to expand

in The Journal of Viral Entry (Volume 4 Issue 1 / Leading Articles)

Samantha J Westrop, BSc1, Graeme J Moyle, MD2, and Nesrina Imami, MD, PhD1

in The Journal of Viral Entry (Volume 4 Issue 1 / Leading Articles)

Eva Poveda, PhD, Eduardo Seclén, PhD, and Vincent Soriano, PhD, MD

Case StudyClick to expand

in The Journal of Viral Entry (Volume 4 Issue 1 / Case Study)

Jörg Hofmann, PhD1, Detlev H Krüger, MD1, and Gero Hütter, MD2

Clinical ReviewsClick to expand

in The Journal of Viral Entry (Volume 4 Issue 1 / Clinical Reviews)

in The Journal of Viral Entry (Volume 4 Issue 1 / Clinical Reviews)

in The Journal of Viral Entry (Volume 4 Issue 1 / Clinical Reviews)

in The Journal of Viral Entry (Volume 4 Issue 1 / Clinical Reviews)

in The Journal of Viral Entry (Volume 4 Issue 1 / Clinical Reviews)

in The Journal of Viral Entry (Volume 4 Issue 1 / Clinical Reviews)

in The Journal of Viral Entry (Volume 4 Issue 1 / Clinical Reviews)

Meeting ReportsClick to expand

in The Journal of Viral Entry (Volume 4 Issue 1 / Meeting Reports)

Vincent Soriano, MD, PhD

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February 23, 2012

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Produced and published by Remedica Medical Education and Publishing Limited.

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Samantha J Westrop, BSc¹, Graeme J Moyle, MD², and Nesrina Imami, MD, PhD¹

Jörg Hofmann, PhD¹, Detlev H Krüger, MD¹, and Gero Hütter, MD²

Samantha J Westrop, BSc¹, Graeme J Moyle, MD², and Nesrina Imami, MD, PhD¹

Jörg Hofmann, PhD¹, Detlev H Krüger, MD¹, and Gero Hütter, MD²